Applies only to oral form of both agents. The dosing for iron replacement treatment in pediatric patients with Peritoneal or Hemodialysis-Dependent - CKD or Non-Dialysis Dependent CKD have not been established. Use Caution/Monitor. Evaluate the hematologic response (hemoglobin, ferritin, iron and transferrin saturation) at least one month following the second Feraheme infusion. Am J Hosp Pharm. Applies only to oral form of both agents. Minor/Significance Unknown. Monitor Closely (1)deferoxamine decreases levels of iron sucrose by inhibition of GI absorption. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. Iron sucrose can also be mixed in a saline solution and given through an IV over a longer time. This health tool computes the required parenteral iron replacement dose for the iron deficit extracted from the patient weight and hemoglobin level from complete blood count test. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Serious - Use Alternative (1)iron sucrose decreases levels of fleroxacin by inhibition of GI absorption. There is limited experience with administration of an infusion of 500 mg of Venofer, diluted in a maximum of 250 mL of 0.9% NaCl, over a period of 3.5 to 4 hours on Day 1 and Day 14. Recommended starting dose 1 Aranesp is dosed at 2.25 mcg/kg SC QW or 500 SC Q3W 1 (SC = subcutaneous) Before initiating 1: Evaluate iron status; administer supplemental iron therapy as needed Correct or eliminate other causes of anemia Initiate 1: Only when Hb < 10 g/dL Minor (2)calcium acetate decreases levels of iron sucrose by inhibition of GI absorption. Fulminant symptoms include confusion, sensation of passing out, paleness. deferasirox decreases levels of iron sucrose by inhibition of GI absorption. Applies only to oral form of both agents. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Serious - Use Alternative (1)iron sucrose decreases levels of gemifloxacin by inhibition of GI absorption. Anemia of chronic disease (ACD), Calculation of the Total Iron Deficit equation appears in Cosmofer PI, Iron Dextran Dosing Calculator (iron deficit). DOSAGE AND ADMINISTRATION: Venofer must only be administered intravenously either by slow injection or by infusion. Minor/Significance Unknown. Pregnancy: Risk Summary-Clinical Considerations. Divide the calculated dose by the patient's weight (IBW if BMI >30, or actual body weight (ABW) if BMI30) to ensure it does NOT exceed 20mg/kg. Contraindicated. Monitor Closely (1)iron sucrose decreases levels of liothyronine by inhibition of GI absorption. Please note that once you have closed the PDF you need to click on the Calculate button before you try opening it again, otherwise the input and/or results may not appear in the pdf. Minor/Significance Unknown. Applies only to oral form of both agents. Reference www.medicines.org.uk Background Use Caution/Monitor. 2010;18(3). A maximum dose of 1000 mg iron can be delivered intravenously over 15 minutes, which may make it a suitable treatment for iron-deficiency anaemia outside of the hospital setting. Below the form there are further instructions on how to use the calculator. This website also contains material copyrighted by 3rd parties. [. Minor (1)iron sucrose, captopril. Where C= concentration of elemental iron (mg/ml) in the product being used: Data from Ferrlecit postmarketing spontaneous reports indicate that individual doses exceeding 125 mg may be associated with a higher incidence and/or severity of adverse events, Adult Patients with Hemodialysis Dependent-Chronic Kidney Disease (HDD-CKD), Adult Patients with Non-Dialysis Dependent-Chronic Kidney Disease (NDD-CKD), WARNING: RISK FOR SERIOUS HYPERSENSITIVITY/ANAPHYLAXIS REACTIONS, Iron Deficiency and Anemia- signs and therapeutic options. Adult Patients: The most common adverse reactions (2%) include diarrhea, nausea, vomiting, headache, dizziness, hypotension, pruritus, pain in extremity, arthralgia, back pain, muscle cramp, injection site reactions, chest pain and peripheral edema. Minor/Significance Unknown. Do not double the dose to catch up. esomeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Applies only to oral form of both agents. This may be helped by giving the medication more slowly or at a lower dose. Dosing Administration & Considerations . For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or For all products, slow initial infusion is prudent; the patient is observed closely for infusion reactions. Ganzoni AM. Discuss the risks and benefits with your doctor.This medication passes into breast milk. All Rights Reserved. Applies only to oral form of both agents. Only administer Feraheme as an intravenous infusion over at least 15 minutes and only when personnel and therapies are immediately available for the treatment of anaphylaxis and other hypersensitivity reactions. Hemoglobin there are two fields for hemoglobin input, one for the target and another for actual value. The usual total treatment course of Venofer is 1000 mg. Venofer treatment may be repeated if iron deficiency reoccurs. Taking the case of a patient weighing 75 kg (165.3 lbs) with a target hemoglobin value of 13 g/dL (130 g/L or 8.07 mmol/L), an actual hemoglobin of 9.5 g/dL (95 g/L or 5.9 mmol/L) and iron stores of 500 mg, the iron deficit is: Iron deficit = 75 x (13 9.5) x 2.4 + 500 = 1,130 mg. Reactions have occurred following the first dose or subsequent doses of Venofer. Use Caution/Monitor. Use Caution/Monitor. concentration of elemental iron (mg/ml) in the product being used: This calculator will help pinpoint potential causes of anemia based on an automated flowchart approach. Finally, a 400-mg dose by 2-hour infusion was examined in 35 patients, but 2 patients experienced such symptoms as hypotension, nausea, and lower back pain. Equations : Total body iron deficit (mg) = body weight (kg) x (target Hb - actual Hb in g/dL) x 2.4 + iron depot (mg)** [1, 2] Iron depot: 15 mg/kg for body weight less than 35 kg 500 mg for those with a body weight greater than or equal to 35 kg Ideal Body Weight (kg) =45.5 +2.3 * (height inches - 60 inches) [3] These are real scientific discoveries about the nature of the human body, which can be invaluable to physicians taking care of patients. Avoid or Use Alternate Drug. Dilute Venofer in a maximum of 250 mL of 0.9% NaCl [see How Supplied/Storage and Handling (16.2).] Applies only to oral form of both agents. The dosing for iron replacement treatment in pediatric patients with HDD-CKD has not been established. *Repeat dose if iron deficiency anemia reoccurs. Deferoxamine chelates iron. Data from Ferrlecit postmarketing spontaneous reports indicate that individual doses exceeding 125 mg may be associated with a higher incidence and/or severity of adverse events. Ferrlecit has been administered at sequential dialysis sessions by infusion or by slow intravenous injection during the dialysis session itself. Modify Therapy/Monitor Closely. View the formulary and any restrictions for each plan. Many people using this medication do not have serious side effects.Severe dizziness or fainting (hypotension) may occur while you are receiving IV iron. The elemental iron product used is Iron sucrose 20 mg/mL. Your doctor will do laboratory tests to monitor your response. https://www.uptodate.com/ (Requires subscription). Iron deficit - equation derivation: Assumptions: -Blood volume = 65 mL/kg -Hemoglobin conc target =14.0 g/dL -Deficits in body stores are ignored. . FERAHEME was non-inferior to Venofer (iron sucrose) in mean Hgb rise from baseline 2,5. iron sucrose decreases levels of levothyroxine by inhibition of GI absorption. Adult Patients with Hemodialysis Dependent-Chronic Kidney Disease (HDD-CKD): Administer Venofer 100 mg undiluted as a slow intravenous injection over 2 to 5 minutes, or as an infusion of 100 mg diluted in a maximum of 100 mL of 0.9% NaCl over a period of at least 15 minutes, per consecutive hemodialysis session. The dosage of Venofer is expressed in mg of elemental iron. Recommended dosing and infusion rates for PI. Use Caution/Monitor. Minor/Significance Unknown. Mean Corpuscular Hemoglobin Concentration (MCHC) Calculator, Red Blood Cell (RBC) Indices Calculator, Iron Deficiency In Pregnancy Calculator. Med J Aust; 193(9):525-32. Mode of Administration: Administer Venofer only intravenously by slow injection or by infusion. Applies only to oral form of both agents. Iron metabolism needs to be balanced and bleeding, the major cause of iron deficiency (for instance in menstruation in females and chronic occult gastrointestinal bleeding) needs to be addressed. All Rights Reserved. Kumpf VJ. Only administer Venofer when personnel and therapies are immediately available for the treatment of serious hypersensitivity reactions. The recommended dosage of iron sucrose for repletion of iron deficiency in patients undergoing hemodialysis is 5ml of iron sucrose (100mg of elemental iron) delivered intravenously during the dialysis session. sodium citrate/citric acid will decrease the level or effect of iron sucrose by increasing gastric pH. Written by ASHP. Applies only to oral form of both agents. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. 2.1 Dosage - Total dose infusion The dose calculation for CosmoFer is based on patients body weight according to the table below and is diluted in 500mLs of normal saline. ]Venofer treatment may be repeated if iron deficiency reoccurs. Injection: 50 mg/2.5 mL, 100 mg/5 mL, or 200 mg/10 mL (20 mg/mL) in single-dose vials. Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when Venofer is injected. Do not administer Venofer to patients with iron overload. The factor 2.4 comes about from the calculation that the total iron content of hemoglobin is 0.34%, the blood volume accounts for 7% . Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. 2015: 763576. Avoid or Use Alternate Drug. Treatment of anemia due to iron deficiency. Monitor Closely (1)calcium carbonate will decrease the level or effect of iron sucrose by increasing gastric pH. STORAGE: Consult the product instructions and your pharmacist for storage details. By taking into account the case of a patient weighing 78 kg (172 lbs) and having a hemoglobin level of 11 g/dL (110 g/L or 6.83 mmol/L). Hemoglobin can be input in g/dL, g/L or mmol/L and refers to the amount of hemoglobin in the red blood cells. Applies only to oral form of both agents. Applies only to oral form of both agents. No data are available regarding overdosage of Venofer in humans. These adverse reactions have occurred up to 30 minutes after the administration of Venofer injection. Here are the steps to follow for using this drug dosage calculator: First, enter the value of your Weight and choose the unit of measurement from the drop-down menu. Your body may also need more iron if you use the drug erythropoietin to help make new red blood cells.Iron is an important part of your red blood cells and is needed to transport oxygen in the body. 1995 Mar-Apr;11(2):163-8. iron sucrose decreases levels of minocycline by inhibition of GI absorption. Accessed: 4/12/2011. Use Caution/Monitor. Each mL contains 20 mg of elemental iron. with NDD-CKD or PDD-CKD who are on erythropoietin therapy for iron maintenance treatment, Hemodialysis-dependent chronic kidney disease (HDD-CKD)*, Non-dialysis-dependent chronic kidney disease (NDD-CKD), Peritoneal-dialysis-dependent chronic kidney disease (PDD-CKD), At a dose of 0.5 mg/kg, not to exceed 100 mg per dose, Given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at concentrations of 1 to 2 mg/mL and administered over 5 to 60 minutes, An increase in Hb concentration or a decrease in ESA dose is desired and. Where: Medicine concentration Amount of active substance per a given volume of your drug. Use Caution/Monitor. UpToDate. Coadministration of ciprofloxacin with multivalent cation-containing products may reduce the bioavailability of ciprofloxacin by 90%. sodium sulfate/?magnesium sulfate/potassium chloride decreases levels of iron sucrose by inhibition of GI absorption. and formulary information changes. Applies only to oral form of both agents. Applies only to oral form of both agents. iron sucrose decreases levels of moxifloxacin by inhibition of GI absorption. Applies only to oral form of both agents. The two formulas used are presented below: Iron deficit in mg = Weight in kg x (14 - Hb in g/dL) x 2.145 Volume of product required in mL = Iron deficit in mg / C in mg/mL Where C is the concentration of the iron product: 50 mg/mL for Iron dextran; 20 mg/mL for Iron sucrose; 5 mg/mL for Ferric gluconate. Monitor Closely (1)trientine, iron sucrose. The Ganzoni equation used by the iron deficiency calculator is the following: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores The recommendation is that most adults need a cumulative dose of elemental iron of at least 1 g. Applies only to oral form of both agents. Anemia; 2015: 763576. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. an automated flowchart approach. cimetidine will decrease the level or effect of iron sucrose by increasing gastric pH. Use Caution/Monitor. Adult Patients with Non-Dialysis Dependent-Chronic Kidney Disease (NDD-CKD): Administer Venofer 200 mg undiluted as a slow intravenous injection over 2 to 5 minutes or as an infusion of 200 mg in a maximum of 100 mL of 0.9% NaCl x 15 minutes. Serum iron, total iron binding capacity (TIBC) and percent saturation of transferrin are other important tests for detecting and monitoring the iron deficient state. Use Caution/Monitor. It is unlikely . Applies only to oral form of both agents. Anemia; 2015: 763576. Volume of iron product required = 25 mL. pantoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. David McAuley, Pharm.D. Schweiz Med Wochenschr; 100(7):301-3. Applies only to oral form of both agents. Your dosage and length of treatment are based on your medical condition, age, and response to treatment. iron sucrose decreases levels of penicillamine by inhibition of GI absorption. For males: LBW = 50 kg + 2.3 kg for each inch of patients height over 5 feet For females: LBW = 45.5 kg + 2.3 kg for each inch of patients height over 5 feet Administration: I. iron sucrose decreases levels of oxytetracycline by inhibition of GI absorption. 3) Bayraktar UD, Bayraktar S. (2010) Treatment of iron deficiency anemia associated with gastrointestinal tract diseases. Venofer is indicated for the treatment of iron deficiency anemia (IDA) in patients with chronic kidney disease (CKD). Inspect parenteral drug products visually for the absence of particulate matter and discoloration prior to administration. Consult your doctor for more details.Remember that it is best to get your vitamins and minerals from food whenever possible. If you log out, you will be required to enter your username and password the next time you visit. Venofer can be given as a maximum of 200mg not more than 3 times per week; doses must be 24 hours apart. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown. Slow or stop the infusion if adverse reactions occur. Sodium ferric gluconate (Ferrlecit) 62.5 mg . Ferric gluconate: 12.5 mg/mL. Corrected Sodium and Effective Osmolality. Applies only to oral form of both agents. Talk to your pharmacist for more details.During pregnancy, this medication should be used only when clearly needed. In less advanced cases of iron deficiency, increases in dietary intake of iron may be sufficient. iron sucrose, benazepril. Monitor Closely (1)rabeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Copyright 2021 GlobalRPH - Web Development by. The cost of Venofer is $145 for a dose of 300 mg and Monoferric is $274 for a dose of 500mg. Ferrlecit may be diluted in 100 mL of 0.9% sodium chloride administered by intravenous infusion over 1 hour per dialysis session. Monitor Closely (1)nizatidine will decrease the level or effect of iron sucrose by increasing gastric pH. Minor/Significance Unknown.iron sucrose increases levels of calcium gluconate by enhancing GI absorption. The therapeutic management of IDA focuses on the replenishment of the iron stores through methods that have been mentioned above. DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. Avoid or Use Alternate Drug. Use Caution/Monitor. trientine, iron sucrose. feasible, Maximum total cumulative iron sucrose dose administered in 14 days is 1000 mg elemental iron. Hemoglobin iron deficit = 60 x (14 - 8) x (2.145) = 772 mg iron. Monitor Closely (1)iron sucrose decreases levels of deferiprone by enhancing GI absorption. Minor/Significance Unknown. 2 DOSAGE & ADMINISTRATION Venofer must only be administered intravenously either by slow injection or by infusion. Med J Aust. Calculation of Dosage of Nefrofer Total Iron Deficit (mg) Nefrofer (ml) = 20mg/ml Total Iron Deficit (mg) = Body weight (kg) x (Target Hb - Actual Hb) [g/l] x 0.24* + Depot Iron . UpToDate. Monitor Closely (1)pantoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Administer Venofer 200 mg undiluted as a slow intravenous injection over 2 to 5 minutes or as an infusion of 200 mg in a maximum of 100 mL of 0.9% NaCl over a period of 15 minutes. Applies only to oral form of both agents. Allow at least 30 minutes between administration of Feraheme and administration of other medications that could potentially cause serious hypersensitivity reactions and/or hypotension, such as chemotherapeutic agents or monoclonal antibodies. 1988 May;111(5):566-70. Venofer is manufactured under license from Vifor (International) Inc., Switzerland. The dosage of Venofer is expressed in mg of elemental iron. FERAHEME Dosing & Administration - Feraheme FERAHEME has flexible dosing for your patients FERAHEME flexible scheduling gives your patients the freedom to receive the iron they need as early as 3 days apart 1 FLEXIBLE DILUTION OPTIONS 1 Dilute full contents of vial (17 mL) in 50 mL to 200 mL of: 0.9% NaCl, or 5% dextrose STORAGE 1
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